NK-cell phenotype at interruption underlies widely divergent duration of CD4+-guided antiretroviral treatment interruption
نویسندگان
چکیده
منابع مشابه
CD4+ count-guided interruption of antiretroviral treatment.
BACKGROUND Despite declines in morbidity and mortality with the use of combination antiretroviral therapy, its effectiveness is limited by adverse events, problems with adherence, and resistance of the human immunodeficiency virus (HIV). METHODS We randomly assigned persons infected with HIV who had a CD4+ cell count of more than 350 per cubic millimeter to the continuous use of antiretrovira...
متن کاملCD4+ guided antiretroviral treatment interruption in HIV infection: a meta-analysis.
The aim of this meta-analysis study was to evaluate the relative risk of death or AIDS-defining events associated to CD4+ guided treatment interruption in patients with chronic HIV infection. A search was conducted using PubMed and Cochrane Library; key words for PubMed were: "antiretroviral therapy and interrupt*" in the full papers from January 1, 2000 up to and including December 31, 2007. T...
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The striking improvement of HIV infec-tion–related morbidity and mortality after the introduction of HAART in the mid 1990s [1] was followed by the daunting realization that eradication of HIV infection is not possible with current antiret-rovirals and that prolonged HAART leads to substantial abnormalities in the metabolism of glucose and lipids, which may accelerate the progression of atheros...
متن کاملInterruption of antiretroviral treatment in HIV-infected children
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متن کاملStructured Treatment Interruption
4 In the context of this discussion, a subtle distinction is made between structured treatment interruption (STI) and structured intermittent treatment (SIT). STI has generally referred to 1 or more periods of interruption of potent antiretroviral therapy after a period of full viral suppression, with the principal goal being stimulation of HIV-1-specific immune responses that might subsequentl...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2011
ISSN: 0953-8178,1460-2377
DOI: 10.1093/intimm/dxq462